His work with SNA-gold nanoparticle conjugates introduced the concept of a nanoparticle as an atom and nucleic acids as bonds, and it laid the ground work for the fields of colloidal crystal engineering with DNA and molecular diagnostics based upon well-defined nanoparticle and nanocrystal bioconjugates. Retrieved 14 November These discoveries and innovations have led to over commercial products that are being used worldwide. Chemistry , Materials science , and Nanotechnology. Retrieved 24 April The former have a plausible though certainly not well characterized mechanism: The SmartFlare is a minor part of the article.
Retrieved January 31, They are being tested for antisense gene regulation, which has been demonstrated both in vivo and in vitro. Nanobiosystems, Medicine, and Health” and “Synthesis, Processing, and Manufacturing of Components, Devices, and Systems” to the world study on nanotechnology research directions for societal needs Nanotechnology Research Directions for Societal Needs in Dickinson College , Pennsylvania State University. There may only be a couple mRNA copies in the cytosol that need to interact with a complementary oligo in order to observe knockdown. Retrieved 21 January
In fact, taking advantage of lower endosomal pH to dissociate nucleic acid carriers is a well-known strategy for facilitating endosomal escape of oligonucleotides.
A RESPONSE FROM CHAD MIRKIN’S GROUP [follow up #1/n] | Rapha-z-lab
Chad Alexander Mirkin born November 23, is an American chemist. Mine is not an indiscriminate bashing but a careful candid critique, based on published papers including their massive holesbasic knowledge of cell biology, as well as our own results: Notify me of new posts via email. You are commenting using your Google account. Given that we are talking about experiments on humans, I would have thought that this is a pretty serious concern.
Like Liked by 1 person. He is the George B. If desorption occurs due to breaking of the Au-S bond, there cannot be specificity. Retrieved 7 May Reference  correspond to six half a dozen articles, 80a to 80f see below tjesis details and links. Yes, your summary is pretty much what I was getting at. Royal Society of Chemistry.
Archived from the original on 14 November Mirkin has pioneered the use of DNA and nanoparticles as synthons in materials science and the development of nanoparticle -based biodiagnostics. Antisense gene regulation cannot happen without the particles going out of the endosomes.
Sorry, your blog cannot share posts by email. His work with SNA-gold nanoparticle conjugates introduced the concept of a nanoparticle as an atom and nucleic acids as bonds, and it laid the ground work for the fields of colloidal crystal engineering with DNA fhad molecular diagnostics based upon well-defined nanoparticle and nanocrystal bioconjugates.
I agree; edited accordingly. I am not sure if I am repeating a citation that is already been provided in this post but low pH seems to stabilize the S-AuNP bond: Why is there no direct evidence when it would be so easy to do and even with some efforts quantify? Let me refine those last sentences: Out of these six, only two are actual research papers, and, thssis both, the SmartFlares are a very minor addition to the work.
Retrieved from ” https: Wrighton on microelectrode devices for electrocatalysis. Mirkin is known for his development of nanoparticle-based biodetection schemes, the invention of dip-pen nanolithography recognized by National Geographic as one of the top scientific discoveries that thesid the worldand contributions to supramolecular chemistry, nanoelectronics, and nanooptics.
A follow up paper by the same group is discussed here. Retrieved 14 November The author is a journalist working for the magazine, not a practicing mirmin. Views Read Edit View history.
ChemistryMaterials scienceand Nanotechnology. The former have a plausible though certainly not well characterized mechanism: This is the most basic, surprising, unexpected and critical feature of these materials. Learn how your comment data is processed.
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