CURRICULUM VITAE SFEIR

Agnel Sfeir is mainly interested in understanding the basic mechanism that leads to telomere length resetting. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival. Stop pulling my strings – what telomeres taught us about the DNA damage response. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. Opens in a new tab.

The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. Is this your profile? Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. The linearity of chromosomes creates two major problems for eukaryotic cells: The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks.

Ramin Haerizadeh Curriculum Vitae

See All Publications Is this your profile? Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining. Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence.

The linearity of chromosomes creates two major problems for eukaryotic cells: Skip to Main Content. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. The former stems from the inherent inability of the replication machinery to fully duplicate linear templates.

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curriculum vitae sfeir

Stop pulling my strings – what telomeres taught us about the DNA damage response. A second area of their interest is to understand how telomere dynamics impact stem curriculjm function and leads to tumorigenesis, using the mouse as a model organism.

curriculum vitae sfeir

A second area of interest to us is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism. Associate Professor, Department of Cell Biology. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival.

curriculum vitae sfeir

Journal of Cell Science. Our lab is mainly interested in understanding the basic mechanism that leads to telomere length resetting.

Non-telomeric role for Rap1 in regulating metabolism and protecting against obesity. Areas of Research Interest and Expertise: PhD from Southwestern University. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival.

Agnel Sfeir is mainly interested in understanding the basic mechanism that leads to telomere length resetting.

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Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. The linearity of chromosomes creates two major problems for eukaryotic cells: The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. Stressed telomeres without POT1 enhance tumorigenesis [Editorial].

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Telomeres at a glance. Opens in a new tab. Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles curdiculum they ultimately undergo cellular senescence. The former stems from the inherent inability of the replication machinery to fully duplicate linear templates.

In particular, we rely on nuclear reprograming as a platform to identify factors that regulate telomere length. Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. Mammalian polymerase theta promotes alternative-NHEJ and suppresses recombination.