We compared the amnesic action, recovery process, and satisfaction of patients and surgeons after the use of 2 different sedation regimens for 40 patients undergoing scheduled implant surgery. Twenty-one adverse events were noted in 17 patients, including 4 neurologic manifestations. The analgesia was assessed using visual analogue scale VAS and patients in both the groups showed 0 scores during the entire surgical period. Obstetric patients with KFS can present unique challenges in administering anesthesia and analgesia, primarily as it relates to the airway and dexmedetomidine infusion has shown promising result to manage the airway through awake fiberoptic intubation without any adverse effects on mother and fetus. Fiberoptic intubation is the gold standard technique for difficult airway management in patients of temporomandibular joint.

Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. At time 0, the concentration of dexmedetomidine was between 3. The present study was aimed to evaluate the clinical effects of dexmedetomidine infusion as anaesthetic adjuvant during middle ear surgery using operating microscope. Sedation score was determined at 15, 30, 60 min after tracheal extubation and time to first analgesic request was recorded. The anesthetic management of neurosurgical patients who possess these contraindications but would be optimally treated by an awake procedure remains unclear. DEX can be titrated to the desired level of sedation without significant respiratory depression [ 27 ]. Hemodynamic variables, total intra-operative fentanyl consumption, emergence time and time to first analgesic request were recorded.

Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking.

Although the plasma albumin concentrations Full Text Available Many patients theesis admitted to the intensive care unit ICU for acute intoxication, serious complication of overdose, or withdrawal symptoms of illicit drugs.

We found very few perioperative complications associated with the use of dexmedetomidine during these challenging cases. Statistical Analyses All variables were tested for normal distribution using the Shapiro-Wilk test. Quantifying memory and sedation effects during dexmedetomidine infusion in verbal children was possible and demonstrated that memory function was present until shortly before verbal unresponsiveness occurred.


Choosing a Thesis Topic – SMS Anaesthesia Thesis Centre

Further studies are needed looking at adverse events associated with dexmedetomidine use in. Hemodynamic responses to dexmedetomidine in critically injured intubated pediatric burned patients: No difference in sedation was detected between the two groups during a controlled range of target plasma concentrations. The data on hemodynamics at various stages of the procedure, dexmeeetomidine complications, total amount of fentanyl used, intravenous fluids required, blood loss and transfusion, duration of surgery, Intensive Care Unit ICU dedmedetomidine, and hospital stay were collected.

dexmedetomidine thesis topics

However, use of DEX is contraindicated in patients with hepatic failure, hypovolemic shock, advanced heart block or ventricular dysfunction. High-performance liquid chromatography testing was performed to determine the concentration at Days 1 through Arrhythmia occurring during and after surgery is one of the major complications in open-heart surgery.

Oxidative Medicine and Cellular Longevity

The evidence was very much visible in the prolonged time to two segmental dermatomal regression Each mare was also assigned a VAS score by each surgeon for the overall satisfaction of analgesia during the entire procedure. Further, our findings provide evidence to suggest that reduction of postoperative inflammatory and oxidative stress plays important role in DEX postoperative analgesic effects, although detailed mechanism needs further study. Full Text Available Patients with Klippel-Feil Syndrome KFS have congenital fusion of their cervical vertebrae due to a failure in the normal segmentation of the cervical vertebrae during the early weeks of gestation and also have myriad of other associated anomalies.

Following surgery, IL-6 levels are associated with dexmedetomidne pain [ 42 ]. The patients were to have 3 dental implants to be placed and flap and bone graft were to be performed during surgery. No bradycardia HR patients, the MAP decreased to patients, three patients completed the study receiving the highest infusion dose of Dex 2. Total numbers of 60 patients between years old and candidate for elective trans-sphenoidal resection of pituitary adenoma were randomLy allocated to two groups; Dexmedetomidine infusion 0.

A total of 60 patients were recruited. The perioperative infusion of dexmedetomidine has a pivotal role toics attenuating the incidence and severity of chronic pain and improving the quality of life in cases undergoing breast cancer surgery.


dexmedetomidine thesis topics

Dexmedetomidine -related polyuria in a pediatric patient. Mean arterial pressure, heart rate, and bispectral index values were recorded every 10min. Alpha2-adrenergic receptor activation triggers intense analgesic response. Future randomized studies will determine the role of dexmedetomidine in the pain management of obese adolescents undergoing bariatric surgery.

dexmedetomidine thesis topics

In a model of diet-induced obesity, we compared the short-term effects of dexmedetomidine versus propofol on lung mechanics and histology, as well dexmedetomidins biological markers of inflammation and oxidative stress modulation in obesity. Thereafter, each dog received one of the following treatments loading dose, CRI: Both dexmedetomidine and clonidine failed to blunt the increase in hemodynamic responses heart rate and blood pressure during intubation, nasal packing, speculum insertion and extubation.

In this model of diet-induced obesity, a 1-hour propofol infusion. The aim of this study was to evaluate the effect of dexmedetomidine on shivering during spinal anesthesia. Therefore, we performed stability testing on compounded dexmedetomidine prepared in two types of intravenous infusion bags for 14 days.

We found that dexmedetomidine prolongs duration of motor block, provides safe and effective sedation without increasing the incidence of side effect in the patients under spinal anesthesia. Despite eexmedetomidine parathyroidectomies to treat hypercalcaemic crisis, mortality rates remain high.

It analyzes possible mechanisms of the cardioprotective effect of dexmedetomidine ropics sympatholysis, favorable effects on the coronary circulation and relief of the coronary steal syndrome in originally ischemized areas of the myocardium, antiinflammatory and antioxidant effects, and prevention of apoptosis activation. As most anesthetic agents will affect ECoG, they should be minimized or stopped prior to any to;ics.